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© Technische Universität Berlin, Exzellenzcluster UniSysCat / Foto: Moritz Kretzschman

Reinventing nature – UniSysCat Cluster of Excellence

At the Cluster of Excellence Unifying Systems in Catalysis (UniSysCat) at Technische Universität Berlin, scientists are researching the future of ‘green chemistry’. The aim is to conserve resources, work energy-efficiently and avoid waste.

Greenopolis looks like modern science fiction: a factory city with trees growing on the roofs and no waste. Only clean water flows out of a beak-shaped drainage pipe into the ditch that surrounds the city. This is how the Unifying Systems in Catalysis (UNISYSCAT) Cluster of Excellence at the Technical University of Berlin presents the basic principle of its research in a comic strip: learning from nature to ensure the quality of human life.

In the short introductory film that the Cluster of Excellence is showing in the Humboldt Lab’s inaugural exhibition After Nature, this principle is explained using the example of photosynthesis: plants absorb carbon dioxide and water and convert both into oxygen and sugar with the help of light energy – substances that other organisms need to live. An ingenious concept that utilises natural solar energy and produces no waste. In this way, plants counteract the man-made climate crisis by absorbing and converting the greenhouse gas carbon dioxide. The result is plant-based food for animals and humans and plenty of wood, which is a safe and useful way of storing solar energy.

The UniSysCat scientists want to understand what happens during such processes, in which many individual chemical reactions build on each other. ‘The next step is then to recreate such structures and see what changes when we turn certain dials,’ explains Holger Dobbek, Professor of Structural Biology and Biochemistry at Humboldt-Universität and one of the spokespersons for the Cluster of Excellence. The aim is to take natural processes such as photosynthesis as an example in order to be able to produce new compounds with light and, for example, to produce fuel from light with carbon dioxide and water. ‘What we are doing is like reinventing nature all over again,’ says cluster spokesperson Arne Thomas, Professor of Functional Materials at the Technical University of Berlin.

Green chemistry: conserving resources and bringing products into a cycle

Emulating nature is certainly good, but improving it sounds like an insane task. And it is. After all, the great role model not only operates a huge, global network of photosynthesis factories with its forests, it also has a certain time advantage. ‘Plants have built up this apparatus over millions of years,’ says cluster spokesperson Matthias Drieß, Professor of Organometallic Chemistry & Inorganic Materials at the Technical University of Berlin. Humans don’t have that much time, the chemist emphasises. ‘If we wait that long, we will be stuck with the gigantic quantities of man-made climate killer gas carbon dioxide with devastating consequences.’ This is because the ongoing climate change and the production of plastic and toxic waste products mean that humanity is working towards the slow but certain destruction of the Earth.

Plastics and other polymers come from the chemical industry; they pose a huge waste problem. This is another reason why the chemical industry needs to become greener, but also more ethical, i.e. to address the impact of chemical products on the environment, demands Matthias Drieß.

Millions of tonnes of plastics are produced every year without a comprehensive solution for recycling them as urban raw materials. This is where chemistry comes in, emphasises the Cluster of Excellence spokesperson: ‘We need to produce polymers that we know can be elegantly broken down into their basic components again.’ This is how nature does it. It produces something and then breaks it down into its individual parts again – without producing waste.

The term ‘green chemistry’ stands for sustainability. This means: ‘Everything becomes, passes away and is part of a reliable ecosystem. It fits into a larger whole – without there being any waste materials that are ecologically questionable,’ explains Drieß. Another principle of green chemistry is to conserve resources by using substances that occur frequently, explains Arne Thomas. It is also about using energy as sparingly as possible. It is true that nature itself is sometimes wasteful in terms of energy consumption, says Holger Dobbek. But this only applies to areas where there is enough of it. Bacteria, for example, are an example of maximum energy efficiency. They manage with an absolute minimum.

Cultivation of cells of the thermophilic cyanobacterium Thermosynechococcus elongatus (T. elongatus) at approx. 50 °C (under controlled conditions). After extraction and purification, the membrane proteins Photosystem I and Photosystem II are crystallised from the cells and used for X-ray structure analysis. The structures provide information on the molecular mechanisms of the basic photosynthetic processes, e.g. oxygen release.

‘Revolutionising catalysis’

Catalysis is at the centre of the processes being researched at UniSysCat. The Cluster of Excellence has set itself the goal of ‘revolutionising catalysis’. Sounds impressive, but what does that mean? The film that UniSysCat is showing in the Humboldt Lab explains this using a classic from chemistry lessons: the oxyhydrogen reaction. A balloon is filled with a mixture of hydrogen and oxygen. As soon as a flame approaches, the balloon explodes and the hydrogen and oxygen react to form water. If, on the other hand, a catalyst is used, a flame is no longer required. A catalyst is an auxiliary substance that reduces the energy required to set the chemical reaction in motion. It also accelerates the reaction. Catalytic processes are the basis for the production of many everyday items – from detergents, medicines, plastics and adhesives to mobile phones and computers.

This often results in waste products that are difficult to dispose of. So there are reasons why chemicals have such a bad reputation, says Dobbek. After all, it is no coincidence that many people think of factories with unpleasant odours and clouds of smoke rising into the sky from their chimneys.

In Greenopolis, the imaginary dream city of the UniSysCat scientists, things look different. One example of the establishment of a new catalysis process to conserve resources and avoid waste, which is being researched at the Cluster of Excellence, is the production of vitamin A, which the human body cannot produce itself, says Matthias Drieß. It is needed in huge quantities, especially as a food supplement, particularly in factory farming and cosmetics. ‘It goes without saying what standards we are talking about here. If you look at the packaging of foods, vitamin A is often added. This doesn’t come from cod liver oil or carrots, but from the chemical industry, because the demand is very high.’

So far, however, no catalysts have been used in the production process. As a result, waste piles up that has to be recycled, which is energy-intensive, explains the chemist. For this reason, a catalytic cycle process is being developed for the first time, in which the starting materials are converted waste-free by electric current at electrodes in an electrolysis cell.

Scientists from the fields of chemistry, biology, physics and engineering are conducting joint research at UniSysCat. Their aim is to combine complex chemical and biological reactions in modern facilities in such a way that the end result is products that can be further utilised, for example for medicines or cosmetic products.

The Cluster of Excellence, which builds on the predecessor cluster UniCat, began its research projects in summer 2019. In addition to scientists from the universities in Berlin and Potsdam, representatives from several research institutes are also involved, including the Fritz Haber Institute (FHI) of the Max Planck Society and the Helmholtz Centre Berlin (HZB). The John Warner Center for start-ups in Green Chemistry was founded in 2018 to promote innovative ideas in the field of green chemistry. Perhaps the birthplace of many small greenopolises in the future.